منابع مشابه
mRNA splicing variants: exploiting modularity to outwit cancer therapy.
Systemic cancer therapy has traditionally exploited vulnerabilities in cancer cells, a strategy which has become more precise with the identification and targeting of driver oncogenes. However, persistent tumor growth due to primary (de novo) or secondary (acquired) resistance limits therapeutic efficacy for many patients. Alternative splicing is important for increasing the diversity of the ce...
متن کاملAlternative mRNA Splicing Generates Two Distinct ADAM12 Prodomain Variants
Human ADAM12, transcript variant 1 (later on referred to as Var-1b), present in publicly available databases contains the sequence 5'-GTAATTCTG-3' at the nucleotide positions 340-348 of the coding region, at the 3' end of exon 4. The translation product of this variant, ADAM12-Lb, includes the three amino acid motif (114)VIL(116) in the prodomain. This motif is not conserved in ADAM12 from diff...
متن کاملTwo human ACAT2 mRNA variants produced by alternative splicing and coding for novel isoenzymes.
Acyl coenzyme A:cholesterol acyltransferase 2 (ACAT2) plays an important role in cholesterol absorption. Human ACAT2 is highly expressed in small intestine and fetal liver, but its expression is greatly diminished in adult liver. The full-length human ACAT2 mRNA encodes a protein, designated ACAT2a, with 522 amino acids. We have previously reported the organization of the human ACAT2 gene and t...
متن کاملGene self-control: when pre-mRNA splicing variants become competing endogenous RNAs
Since Richard J. Roberts and Phillip A. Sharp discovered split genes (genes are interrupted by RNA-encoding regions called exons and non-coding segments called introns in eukaryotic genome) in 1970’s, scientists have been finding many genes can generate more than one mRNA transcripts through AS (alternative splicing, e.g., by different exon-exon combination). This AS strategy increases protein ...
متن کاملSplicing of juvenile and adult tau mRNA variants is regulated by thyroid hormone.
The effect of thyroid hormone on the expression of tau transcripts was studied during postnatal brain development. The level of tau mRNA was only slightly changed postnatally in the cerebral hemispheres of hypothyroid rats, whereas the level of tau mRNA in the cerebellum was maintained at a higher level than in the euthyroid controls. As shown by in situ hybridization studies, such an alteratio...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2018
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gky1086